**Abbott's TriClip™ Shows Sustained Benefits in Treating Leaky Tricuspid Heart Valve**
On March 31, 2025, Abbott announced two-year data from its TRILUMINATE™ Pivotal trial demonstrating that the TriClip™ transcatheter edge-to-edge repair (TEER) system provides significant and sustained improvements for patients with severe tricuspid regurgitation (TR), a condition commonly known as a leaky tricuspid heart valve.
Presented at the American College of Cardiology’s ACC.25 conference and published in *Circulation*, the findings show that TriClip significantly reduced hospitalizations due to heart failure and enhanced patients’ quality of life. TR, if left untreated, can lead to serious complications such as heart failure and even death, especially in patients who are not candidates for open-heart surgery.
Key two-year findings include:
- A significant reduction in heart failure hospitalizations: 0.19 vs. 0.26 events per patient-year in the treatment group versus control (p=0.02).
- 84% of TriClip recipients had reduced TR severity to moderate or less, compared to only 21% in the control group. In crossover patients, this rate improved from 3% to 81% within 30 days.
- Patients receiving TriClip experienced an average 15-point improvement on the Kansas City Cardiomyopathy Questionnaire (KCCQ), which measures symptoms and quality of life. Crossover patients reported a 13-point improvement after receiving the device.
Dr. Saibal Kar, a trial investigator, noted that the results confirmed TriClip’s ability to reduce hospitalizations while sustaining improvements in valve function and quality of life.
Sandra Lesenfants, senior vice president of Abbott’s structural heart business, emphasized that TriClip provides a safe and effective alternative for patients with few treatment options.
TriClip is now approved in over 50 countries, including the U.S., Europe, and Canada. The TRILUMINATE Pivotal trial is the first randomized controlled study comparing TriClip to medical therapy for severe TR.